română DAN NICOLAE UNGUREANU, NICOLAE ANGELESCU, VIOLETA TSAKIRIS, VIRGIL MARINESCU
Abstract
In this paper is presented a synthesis method of calcium phosphate bioceramics such as hydroxiapatite, the mineral component of bones and hard tissue in mammals. Hydroxyapatite powders have been obtained by chemical coprecipitation, by using calcium hydroxide and ortophosphoric acid as a source of calcium and phosphorus. The synthesized powders were characterized by X – ray diffraction, dynamic light scattering technique (DLS) and scanning electron microscopy (SEM). The proposed method lead to obtain a hydroxyapatite with a degree of crystallinity, greater than 80%, in case of all samples thermal treated at 8000C.
Keywords
biomaterials, hydroxyapatite, chemical precipitation, x - ray methods, degree of crystallinity
FLORENTINA GRIGORE, MAGDALENA LUNGU, DIANA SAVU, MIHAI RADU, GEORGETA VELCIU
Abstract
Tricalcium phosphate has received a special attention as graft for bone regeneration due to its excellent biocompatibility and biodegradability. In this paper, we prepared β-Ca3(PO4)2 granules that were tested in terms of biocompatibility. Firstly, we obtained the ceramic materials by polymeric sponge technique starting from ultrafine powders of β-TCP obtained in our laboratory and polyurethanes sponge from S.C Poliflex. Secondly, the ceramic foam was grained through a sieve with mesh sizes ranging between 500-1000 μm to obtain the grains. The chemical composition and morphology were investigated using X-ray diffraction analysis (XRD) and optical microscopy (OP). The characteristics of the ceramic slurries were determined with the ZetaPlus Brookhaven device. The biocompatibility of the product was analyzed by evaluation of the cytotoxic effects, using the agar diffusion method.
Keywords
tricalcium phosphate granules, ceramic suspensions, biocompatibility
CHRISTU ŢÂRDEI, SORINA MITREA, OANA CRĂCIUNESCU, ELENA IULIA OPRIŢA, RUXANA TRUŞCĂ
Abstract
Intensive research is conducted both in understanding the phenomenon of "repair / healing of the bone" and for the development of techniques, devices and materials for effective applications involved in bone regeneration. This study is aimed at the development of a method to fabricate porous spherical tri-calcium phosphate (β-TCP) granules, which can be impregnated with a drug. Microspheres were prepared by the ionotropic gelation technique using CaCl2 as cross-linking agent.
The microstructure and composition of ceramic microsphere were investigated by X-ray diffraction (XRD), scanning electron microscopy (SEM). In vitro cell culture tests showed that both ceramic microsphere types were highly biocompatible and favored cell growth during 72 hours of cultivation. Porous tri-calcium phosphate microspheres can be used for bone void filler, but also for drug delivery systems.
Keywords
biomaterials, tri-calcium phosphate, ceramic beads, alginate, ionotropic gelation
MĂDĂLINA GEORGIANA FLOREA, ANTON FICAI, OVIDIU OPREA, CORNELIA GURAN, DENISA FICAI, L. PALL, ECATERINA ANDRONESCU
Abstract
The aim of this work is to obtain new drug delivery systems with prolonged release of biological active folic acid. The prolonged delivery of folic acid, a component of the B complex is essential during the life being responsible with many essential functions including cell division and growth. The obtained materials were characterized by, FTIR and XRD as well as by studying the release profiles of folic acid and water uptake. It can conclude that the release rate is influenced by the used silica precursors.
Keywords
biocomposite materials, silica, DDS, sustained delivery