ALEXANDRU MIHAI GRUMEZESCU, ECATERINA ANDRONESCU, ANTON FICAI, CRINA SAVIUC, DAN MIHĂIESCU, MARIANA CARMEN CHIFIRIUC

Abstract

The desired pharmacological activity with minimum side effects of different traditional chemical formulations is achieved by enabling the site-specific targeting and controlled release. In this study, magnetic diethylaminoethyl-cellulose (DEAE-Cellulose) has been prepared by magnetite nanoparticles deposition on the DEAE-Cellulose support. The primary method to analyze the surface modification was SEM. DEAE-Cellulose/Fe₃O₄ was loaded with different antibiotics and their antimicrobial efficacy against bacterial strains belonging to E. coli and S. aureus species were studied. DEAE-Cellulose/ Fe₃O₄/cephalosporins have been characterized by using FT-IR. Our study indicates that the materials of DEAE-Cellulose/Fe₃O₄/cephalosporins have generally increased the activity against tested strains, the antimicrobial effect being not significantly dependent of temperature treatment.